ABSTRACT
OBJECTIVE:To investigate the effects of sufentanil combined with dexmedetomidine on ICU acquired weakness(ICU-AW)of AECOPD patients receiving mechanical ventilation. METHODS:A total of 120 AECOPD patients in ICU of our hospital during Oct. 2015-Oct. 2016 were divided into group A and B according to random number tablet,with 60 cases in each group. Group A was given analgesia and sedation of sufentanil combined with propofol;group B was given analgesia and sedation of sufentanil combined with dexmedetomidine. RAAS sedation score and British Medical Research Committee(MRC)score were compared between 2 groups before treatment and 7 d after treatment. The incidence of ICU-AW,delirium and tracheal extubation were observed. The staying time in ICU,total hospitalization time and the occurrence of ADR were compared between 2 groups after diagnosed as ICU-AW. RESULTS:After treatment,the scores of RASS sedation degree scale in 2 groups were decreased significantly compared to before treatment,with statistical significance (P<0.05);there was no statistical significance between 2 groups(P>0.05). MRC score of group A was decreased significantly compared to before treatment,and significantly lower than group B,with statistical significance(P<0.05). There was no statistical significance in MRC score of group B before and after treatment(P>0.05). After 7 d of treatment,the incidence of ICU-AW in group B was significantly lower than group A(40.00% vs. 56.67%);the incidence of tracheal extubation in group B was significantly higher than group A(70.00% vs. 53.33%),the incidence of delirium was significantly lower than group A(13.33% vs. 20.00%);the staying time in ICU and total hospitalization time in group B after diagnosed as ICU-AW were significantly shorter than group A,with statistical significance(P<0.05). There was no statistical significance in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Compared with sufentanil combined with propofol, sufentanil combined with dexmedetomide shows similar analgesia and sedation effect,but has better influence on the muscle strength of the patient,reducing the incidence of ICU-AW and delirium,shortening the duration of mechanical ventilation,staying time in ICU and total hospitalization time in AECOPD patients receiving mechanical ventilation,with similar safety.